Patient Education


Alphagan P®
Generic name

Brimonidine tartrate



Mechanism of action

This selective alpha-2 adrenergic agonist reduces the aqueous humor production and increases aqueous humor outflow.

Use with caution in patients with/during
  1. Severe cardiac disease, cerebrovascular disease, or coronary artery disease
  2. Depression; contraindicated in patients receiving monoamine oxedase (MaO) inhibitor therapy
  3. Raynaud's disease, thromboangiitis obliterans (Buerger's disease), depression, and orthostatic hypotension
  4. Contact lens wearers due to the preservative BAK. Drops should be instilled 15 minutes before putting in contacts
  5. Renal impairment or damage or hepatic disease
  6. Pregnancy, breastfeeding, or in children
Common Side effects
  • Ocular allergic reactions
  • Oral dryness
  • Stinging
  • Ocular pruritus (itchy eyes)
  • Ocular hyperemia (red eyes)
  • Headache
  • Foreign body sensation
  • Fatigue
  • Drowsiness
  • Conjunctival follicles (mass of cells on the conjunctiva)
  • Blurring of the eyes
  • Burning of the eyes
Less common to rare side effects
  • Abnormal taste
  • Conjunctival hemorrhage (bleeding of the conjunctiva)
  • Corneal erosion
  • Eyelid erythema (redness of eyelid due to blood vessel dilation)
  • Insomnia
  • Lid crusting
  • Tearing
  • Ocular pain
  • Photophobia (sensitivity to light)
  • Ocular dryness