Faculty Directory

William H. Swanson

Professor

William H. Swanson

OP 504

812-856-4681
wilswans@indiana.edu

Education
  • PhD–1984 (University of Chicago)
Biography

William H. Swanson received his Ph.D. in Biophysics and Theoretical Biology in 1984 from the University of Chicago, where he also completed a postdoctoral fellowship in Ophthalmology and Visual Science from 1984-1987. From 1987 to 1999 he performed clinically-oriented research on a range of eye diseases at the Retina Foundation of the Southwest in Dallas, TX, where he became a Senior Research Scientist and Assistant Research Director. In 1999 Dr. Swanson moved to SUNY State College of Optometry in New York, where his research focused exclusively on glaucoma, and he achieved the rank of full Professor in 2002. In 2006 Dr. Swanson joined the faculty at Indiana University School of Optometry, while maintaining collaborations with clinical researchers at SUNY.

Dr. Swanson has published numerous articles about his research and frequently presents his work at national and international conferences. He is a member of several professional organizations: American Academy of Optometry, Association for Research in Vision and Ophthalmology, Optometric Glaucoma Society, Imaging and Perimetry Society, and Glaucoma Progression Scholars. Dr. Swanson’s honors include the SUNY Chancellor's Award for Excellence in Research, Fellow American Academy of Optometry, SUNY Chancellor's Award for Excellence in Scholarship and Creative Activities, New York State Optometric Association Distinguished Service Award, and Silver Fellow Association for Research in Vision and Ophthalmology.

His research has been funded by NIH since 1991, during which time he has served as a consultant for the National Eye Institute, the Food & Drug Administration, Veteran's Affairs, Fight for Sight, and for several businesses (Alcon Laboratories, Neurotech, Carl Zeiss Meditec, Heidelberg Engineering).

3D RNFL STRUCTURE AND HIGH-RESOLUTION PERIMETRY FOR ASSESSING GLAUCOMATOUS DAMAGE

Glaucoma is one of the leading causes of preventable blindness, and currently available treatments are not sufficient to halt progression in many patients. While much has been learned about the biology of glaucoma, development of new forms of treatment has been stymied by three barriers: high between-subject variability in ganglion cell number in normal eyes, high within-subject variability in patients with glaucoma, and the slow rate of progression of the disease. My current research integrates neural modeling and clinical research to develop improved methods for diagnosing glaucoma and for assessing progression towards blindness. The results are intended to improve measures for both clinical trials and ongoing patient care, while at the same time improving basic science understanding of the pathophysiology of glaucoma and providing guidance for biological studies of the disease process. Innovative uses of clinical devices will guide testing with custom systems, and statistical analyses will utilize the synergy between structural and functional measures of glaucomatous damage.

PSYCHOPHYSICAL MODELS APPLIED TO VISUAL DISORDERS

The long-term objective of my research is to relate functional deficits in patients with visual disorders to underlying cellular pathophysiology. A better understanding of these relations will be useful in design of clinical treatment trials, in selecting and interpreting tests for individual patients, and in guiding biomolecular and physiological studies. The research uses quantitative models, rigorous psychophysical methods, and carefully selected patient populations to investigate the linkage between functional defects and biological damage. This research involves both basic and clinical studies of color vision, spatial vision, and flicker sensitivity. My current focus is on development of new methods for evaluation of progression of glaucomatous vision loss, development of a quantitative model of neural processing in perimetry that relates glaucomatous visual defects to ganglion cell damage, and new methods for comparing structure and function.

Here is a link to William H. Swanson's public Bibliography:

http://www.ncbi.nlm.nih.gov/sites/myncbi/1jSBr_gfa66Q3/bibliograpahy/40415078/public/?sort=date&direction=descending

Publications

PDF Articles

Pearson PM, Swanson WH "Chromatic contrast sensitivity: the role of absolute threshold and gain constant in differences between the fovea and the periphery", Journal of the Optical Society of America A 17:232-243 (2000).

Swanson WH, Fish GE "Color matches in diseased eyes with good acuity: detection of deficits in cone optical density and in chromatic discrimination",Journal of the Optical Society of America A 12:2230-2236 (1996).

Swanson WH, Fish GE "Color matches in diseased eyes with good acuity: detection of deficits in cone optical density and in chromatic discrimination", Journal of the Optical Society of America A 12:2230-2236 (1995).

Swanson WH "Analysis of Rayleigh match data with psychometric functions" Journal of the Optical Society of America A 10:1807-1817 (1993).

Swanson WH "Chromatic adaptation alters spectral sensitivity at high temporal frequencies" Journal of the Optical Society of America A 10:1294-1303 (1993).

Swanson WH, Pokorny J, Smith VC "Effects of chromatic adaptation on phase-dependent sensitivity to heterochromatic flicker" Journal of the Optical Society of America A 5:1976-1982 (1988).

Swanson WH, Pokorny J, Smith VC "Effects of temporal frequency on phase-dependent sensitivity to heterochromatic flicker", Journal of the Optical Society of America A 4:2266-2273 (1987).

Swanson WH, Ueno T, Smith VC Pokorny J "Temporal modulation sensitivity and pulse-detection thresholds for chromatic and luminance perturbations", Journal of the Optical Society of America A 4:1992-2005 (1987).

Web Articles

Stark LR, Kruger PB, Rucker FJ, Swanson WH, Schmidt N, Hardy C, Rutman H, Borgovan T, Burke S, Badar M, Shah R. "Potential signal to accommodation from the Stiles-Crawford effect and ocular monochromatic aberrations." Journal of Modern Optics 56:2203-2216 (2009). PMID: 2083540

Swanson, WH, "Deconstructing the doctrine of "functional reserve". Optometric Glaucoma Society E-Journal 3:1 (2008)

Patel S, Schwartz SH, Swanson WH "Differential vertical visual latency as determined with a simultaneity paradigm" Vision Research 50:534-40 (2010) PMID: 20034513.

Swanson WH, Pan F, Lee BB "Chromatic temporal integration and retinal eccentricity: psychophysics, neurometric analysis and cortical pooling" Vision Research 48:2657-62 (2008).

Sun H, Swanson WH, Arvidson B, Dul MW "Assessment of contrast gain signature in inferred magnocellular and parvocellular pathways in patients with glaucoma" Vision Research 48:2633-41 (2008).

Hot A, Dul MW, Swanson WH "Development & evaluation of a contrast sensitivity perimetry test for patients with glaucoma", Investigative Ophthalmology & Visual Science 49:3049-3057 (2008).

Gardiner SK, Swanson WH, Demirel S, McKendrick AM, Turpin A, Johnson CA, "A two-stage neural spiking model of visual contrast detection in perimetry", Vision Research 48:1859-1869 (2008).

Chen Y, Wyatt HJ, Swanson WH, Dul MW "Rapid pupil-based assessment of glaucomatous damage" Optometry and Vision Science Research 85:471-481 (2008).

Yang A and Swanson WH "A new pattern electroretinogram paradigm evaluated in terms of user-friendliness and agreement with perimetry" Ophthalmology 114: 671-679 (2007).

Wyatt HJ, Dul MW and Swanson WH "Variability of visual field measurements is correlated with the gradient of visual sensitivity" Vision Research 47:925-936 (2007).

Pan F & Swanson WH "A cortical pooling model of spatial summation for perimetric stimuli" Journal of Vision 6:1159-1171 (2006).

Chung I, Bartolone A, Swanson WH, Thau AP "A clinical evaluation of proview pressure phosphene tonometry in children" Optometry and Vision Science 83:817-822 (2006).

Malik R, Swanson WH, Garway-Heath DF "Development and evaluation of a linear staircase strategy for measurement of perimetric sensitivity" Vision Research 46:2956-2967 (2006).

Pan F, Swanson WH & Dul MW "Evaluation of a two-stage neural model of glaucomatous defect: an approach to reduce test-retest variability" Optometry & Vision Science 83:499-511 (2006).

Sun H, Dul MW, Swanson WH "Linearity can account for the similarity between conventional, frequency-doubling, and gabor-based perimetric tests in the glaucomatous macula" Optometry & Vision Science 83:455-465 (2006).

Pearson PM, Schmidt LA, Ly N & Swanson WH "Ganglion cell loss and age-related visual loss: a cortical pooling analysis" Optometry & Vision Science 83:444-454 (2006).

Chen Y, Wyatt HJ, Swanson WH "Pupillary evaluation of retinal asymmetry: development and initial testing of a technique" Vision Research 45:2549-63 (2005).

Swanson WH, Dul MW, Fischer SE "Quantifying effects of retinal illuminance on frequency doubling perimetry", Investigative Ophthalmology & Visual Science 46:235-240 (2005).

Swanson WH, Felius J, Pan F "Perimetric defects and ganglion cell damage: interpreting linear relations using a two-stage neural model", Investigative Ophthalmology & Visual Science 45: 466-472 (2004).

Felius J, Swanson WH "Effects of cone adaptation on variability in S-cone increment thresholds", Investigative Ophthalmology & Visual Science 44: 4140-4146 (2003).

White, AJ, Sun H, Swanson WH and Lee BB "An examination of physiological mechanisms underlying the frequency- doubling illusion". Investigative Ophthalmology and Visual Science, 43: 3590-3599 (2002).

Birch EE, Swanson WH, Wang YZ "Infant hyperacuity for radial deformation", Investigative Ophthalmology and Visual Science 41: 3410-3414 (2000).

Felius J, Swanson WH "Photopic temporal processing in retinitis pigmentosa", Investigative Ophthalmology and Visual Science 40:2932-2944 (1999).

Birch EE, Swanson WH, Stager DR, Woody M, Everett M "Outcome after very early treatment of dense congenital unilateral cataract", Investigative Ophthalmology and Visual Science 34:3687-3699 (1993).

Swanson WH, Birch DG, Anderson JL "S-cone Function in Patients with Retinitis Pigmentosa", Investigative Ophthalmology and Visual Science 34:3045-3055 (1993).

Additional Articles

Swanson WH, Sun H, Lee BB, Cao D "Responses of Primate Retinal Ganglion Cells to Perimetric Stimuli" Investigative Ophthalmology & Visual Science 52:764-71. PMID: 20881286 (2011)

Shafi A, Swanson WH, Dul MW. Structure and Function in Patients with Glaucomatous Defects Near Fixation. Optometry and Vision Science 88:130-9 (2011). PMID20935585

Schwartz SH, Nehmad L, Rosenfield M, Swanson WH, Calero-Breckheime A, Modica P, Picarelli J "Teaching basic science courses uses web-based clinical cases: Experiences with BACIC" Optometric Education 32:23-28 (2006).

Schwartz SH, Swanson WH "Empiric determination of corrected visual acuity standards for train crews" Optometry & Vision Science. 82(8):774-8 (2005).

Swanson WH, Cohen JM, "Color Vision" in Ophthalmology Clinics of North America: Assessing Visual Function in Clinical Practice, edited by P.A. Sample & C.A. Girkin (W. B. Saunders Co., Philadelphia, 2003). 6: 179-203.

Birch DG, Toler SM, Swanson WH, Fish GE, Laties AM "A double-blind placebo-controlled evaluation of the acute effects of sildenafil citrate (Viagra) on visual function in subjects with early-stage age-related macular degeneration", American Journal of Ophthalmology 133:665-672 (2002).

Pearson PM, Swanson WH, Fellman RL "Chromatic and achromatic defects in patients with progressing glaucoma", Vision Research 41: 1215-1227 (2001).

Swanson WH, Felius J, Birch DG "Effect of stimulus size on static visual fields in patients with retinitis pigmentosa" Ophthalmology 107: 1950-1954 (2000).

Pearson PM, Swanson WH "Chromatic contrast sensitivity: the role of absolute threshold and gain constant in differences between the fovea and the periphery", Journal of the Optical Society of America A 17:232-243 (2000).

Birch EE, Swanson WH "Hyperacuity deficits in anisometropic and strabismic amblyopes with known ages of onset", Vision Research 40:1035-1040 (2000).

Pearson PM, Swanson WH, Fellman RL, Lynn JR, Starita RJ "A method for sampling discrete ganglion cell mosaics which decreases threshold variability" Perimetry Update 1998/1999 (M. Wall and J. M. Wild, eds.), pp. 111-117, Kugler Publications, The Hague (1999).

Swanson WH "Book Review: Human Color Vision, 2nd Edition, by Peter Kaiser and Robert M. Boynton", Optometry and Vision Science 74:84 (1998). [Book Review]

Swanson WH, Fiedelman M "Sensitivity and spectral tuning of the red-green chromatic pathway in heterozygous carriers of congenital color vision defects", Colour Vision Deficiencies XIII (CR Cavonius, editor), pp. 77-86, Kluwer Academic Publishers, Dordrecht (1997).

Felius J, Swanson WH, Fellman RL, Lynn JR, Starita RJ, "Spatial summation for selected ganglion cell mosaics in patients with glaucoma," Perimetry Update 1996/1997 (M. Wall and A. Heijl, eds.), pp. 213-221, Kugler Publications, Amsterdam (1997).

Swanson WH, Fish GE, "Age-related changes in the color-match-area effect", Vision Research 36:2079-2085 (1996).

Swanson WH "S-cone spatial contrast sensitivity can be independent of pre-receptoral factors", Vision Research 36:3549-3555 (1996).• Hutton WL, Fuller DG, Snyder WB, Fellman RL, Swanson WH "Visual field defect following macular hole surgery. A new finding", Ophthalmology 103:2152-2159 (1996).

Swanson WH, Fish GE "Color matches in diseased eyes with good acuity: detection of deficits in cone optical density and in chromatic discrimination", Journal of the Optical Society of America A 12:2230-2236 (1995).

Swanson WH, Lynn JR, Fellman RL, Starita RJ, Schumann SP, Nusinowitz S "Inter-operator variability in images obtained by laser polarimetry of the nerve fiber layer", Journal of Glaucoma 4:414-418 (1995).

Swanson WH, Fellman RL, Lynn JR, Starita RJ "S-cone contrast sensitivity in glaucoma as a function of mean luminance" in B. Drum (ed.), Documenta Ophthalmologica Proceedings Series 57:63-71 (1995).

Swanson WH, Lynn JR, Fellman RL, Starita RJ, Schumann SP, Nusinowitz S, Anderson JL "Inter-observer variability in laser ellipsometry of the nerve fiber layer" Perimetry Update 1994/95 (R.P. Mills and M. Wall , eds.) Kugler: Amsterdam, p. 341 (1995)

Swanson WH "Diagnosis of Defective Color Vision, by Jennifer Birch", International Ophthalmology 18:318 (1995). [Book Review]

Swanson WH "Time, Color and Phase" in Visual Science and Engineering: Models and Applications, edited by D. H. Kelly (Marcel Dekker, Inc., New York, 1994) pp. 191-225 [invited chapter]

Swanson WH, Birch DG and Anderson JL "S-cone function in patients with retinitis pigmentosa" Investigative Ophthalmology and Visual Science 35:781-783 (1994). [Letter to Editor]

Swanson WH "Analysis of Rayleigh match data with psychometric functions" Journal of the Optical Society of America A 10:1807-1817 (1993).

Swanson WH "Chromatic adaptation alters spectral sensitivity at high temporal frequencies" Journal of the Optical Society of America A 10:1294-1303 (1993).

Lynn JR, Swanson WH, Fellman RL, Starita RJ "Does glaucomatous visual field loss continue despite surgically subnormal IOP?", in R.P. Mills , ed. Perimetry Update 1992/1993 Kugler: Amsterdam (1993), pp.129-135.

Stager DR, Everett M, Swanson WH "The importance of controlled illumination in color vision testing in a pediatric ophthalmology clinical practice", Journal of Pediatric Ophthalmology and Strabismus 30:39-42 (1993)

Swanson WH, Birch EE "Extracting thresholds from noisy psychophysical data" Perception & Psychophysics 51:409-422 (1992).

Swanson WH, Everett M "Color vision screening of young children", Journal of Pediatric Ophthalmology and Strabismus 29:49-54 (1992). [Reprinted in Journal of Ophthalmic Nursing and Technology 11:164-171, 1992]

Birch EE, Swanson WH "Probability summation of acuity in the human infant", Vision Research 32:1999-2003 (1992).

Swanson WH "Heterochromatic modulation photometry in heterozygous carriers of congenital color defects", Documenta Ophthalmologica Proceedings Series 54:457-471 (1991).

Swanson WH "Effects of phase shifts between cone inputs on responses of chromatically opponent cells”, in A. Valberg & B. B. Lee, eds. From Pigments to Perception Plenum Press: New York, pp. 447-450 (1991).

Lynn JR, Swanson WH, Fellman RL "Evaluation of automated kinetic perimetry (AKP) with the Humphrey Field Analyzer", in R. P. Mills & A. Heijl, eds. Perimetry Update 1990/1991 Kugler: Amsterdam, pp. 433-452 (1991).

Swanson WH, Birch EE "Infant spatiotemporal vision: dependence of spatial contrast sensitivity on temporal frequency", Vision Research 30:1033-1048 (1990).

Swanson WH "Short-wavelength-sensitive cone acuity: individual differences and clinical application", Applied Optics 28:1151-1157 (1989).

Fellman RL, Lynn JR, Starita RJ, Swanson WH, "Clinical importance of spatial summation in glaucoma" in A. Heijl, ed. Perimetry Update 1988/1989 Kugler & Ghendi: Berkeley, pp. 313-324 (1989).

Ueno T, Swanson WH, "Response pooling between chromatic and luminance systems" Vision Research 29:325-333 (1989).

Swanson WH "Color Vision: Assessment and Clinical Relevance", in Ophthalmology Clinics of North America: Assessment of Visual Function for the Clinician, edited by D. G. Fuller & D. G. Birch (W. B. Saunders Co., Philadelphia) pp. 391-413 (1989).

Swanson WH, Pokorny J, Smith VC "Effects of chromatic adaptation on phase-dependent sensitivity to heterochromatic flicker" Journal of the Optical Society of America A 5:1976-1982 (1988).

Swanson WH, Georgeson MA, Wilson HR "Comparison of contrast responses across spatial mechanisms", Vision Research 28:457-459 (1988).

Swanson WH, Pokorny J, Smith VC "Effects of temporal frequency on phase-dependent sensitivity to heterochromatic flicker", Journal of the Optical Society of America A 4:2266-2273 (1987).

Swanson WH, Ueno T, Smith VC Pokorny J "Temporal modulation sensitivity and pulse-detection thresholds for chromatic and luminance perturbations", Journal of the Optical Society of America A 4:1992-2005 (1987).

Swanson WH, Wilson HR "Eccentricity dependence of contrast matching and oblique masking", Vision Research 25:1285-1295 (1985).

Swanson WH, Wilson HR, Giese SC, "Contrast matching data predicted from contrast increment thresholds" Vision Research 24:63-75 (1984).

Swanson WH, "R? in the uniform topology", Journal of Undergraduate Mathematics 10:75-79 (1979).

Research

https://projectreporter.nih.gov/Reporter_Viewsh.cfm?sl=12ECCA034B8BC1D77598B8961CAA4A01A2FFCEB861BF